Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice

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Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice.

An overactive renin-angiotensin system (RAS) is known to contribute to type 2 diabetes mellitus (T2DM). Although ACE2 overexpression has been shown to be protective against the overactive RAS, a role for pancreatic ACE2, particularly in the islets of Langerhans, in regulating glycemia in response to elevated angiotensin II (Ang II) levels remains to be elucidated. This study examined the role o...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism

سال: 2013

ISSN: 0193-1849,1522-1555

DOI: 10.1152/ajpendo.00490.2012